|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:128000), IHC-P (10 µg/ml), WB (1-3 µg/ml)|
|Other Names||Sodium- and chloride-dependent betaine transporter, BGT-1, Na(+)/Cl(-) betaine/GABA transporter, Solute carrier family 6 member 12, SLC6A12|
|Target/Specificity||Human SLC6A12 / BGT-1. Reported variants represent identical protein: NP_001193860.1, NP_003035.3, NP_001116319.1, NP_001116320.1.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||SLC6A12 / BGT-1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain|
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Provided below are standard protocols that you may find useful for product applications.
Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.
Rasola A.,et al.FEBS Lett. 373:229-233(1995).
Borden L.A.,et al.J. Neurochem. 64:977-984(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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