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FUT2 / SE Antibody (N-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q10981 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 39kDa |
| Dilution | ELISA (1:64000), IHC-P (5 µg/ml), WB (1-3 µg/ml) |
| Gene ID | 2524 |
|---|---|
| Other Names | Galactoside 2-alpha-L-fucosyltransferase 2, 2.4.1.69, Alpha(1, 2)FT 2, Fucosyltransferase 2, GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2, SE2, Secretor blood group alpha-2-fucosyltransferase, Secretor factor, Se, FUT2, SEC2 |
| Target/Specificity | Human FUT2 / SE. Reported variants represent identical protein: NP_001091107.1, NP_000502.4 |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | FUT2 / SE Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FUT2 (HGNC:4013) |
|---|---|
| Synonyms | SEC2 |
| Function | Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N- linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PubMed:7876235, PubMed:8018146, PubMed:12692541). Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs (By similarity). Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (PubMed:22068912, PubMed:21625510, PubMed:24733310). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235). |
| Cellular Location | Golgi apparatus, Golgi stack membrane; Single- pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi |
| Tissue Location | Small intestine, colon and lung. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values.
References
Kelly R.J.,et al.J. Biol. Chem. 270:4640-4649(1995).
Kudo T.,et al.J. Biol. Chem. 271:9830-9837(1996).
Koda Y.,et al.Eur. J. Biochem. 246:750-755(1997).
Koda Y.,et al.Am. J. Hum. Genet. 59:343-350(1996).
Liu Y.,et al.Hum. Genet. 103:204-210(1998).
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