|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:64000), IHC-P (5 µg/ml), WB (1-3 µg/ml)|
|Other Names||Galactoside 2-alpha-L-fucosyltransferase 2, 18.104.22.168, Alpha(1, 2)FT 2, Fucosyltransferase 2, GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2, SE2, Secretor blood group alpha-2-fucosyltransferase, Secretor factor, Se, FUT2, SEC2|
|Target/Specificity||Human FUT2 / SE. Reported variants represent identical protein: NP_001091107.1, NP_000502.4|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||FUT2 / SE Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids (PubMed:7876235). The resulting epitope plays a role in cell-cell interaction including host-microbe interaction (PubMed:12692541, PubMed:8018146). Mediates interaction with intestinal microbiota influencing its composition (PubMed:21625510, PubMed:24733310, PubMed:22068912). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235).|
|Cellular Location||Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi|
|Tissue Location||Small intestine, colon and lung.|
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Provided below are standard protocols that you may find useful for product applications.
Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values.
Kelly R.J.,et al.J. Biol. Chem. 270:4640-4649(1995).
Kudo T.,et al.J. Biol. Chem. 271:9830-9837(1996).
Koda Y.,et al.Eur. J. Biochem. 246:750-755(1997).
Koda Y.,et al.Am. J. Hum. Genet. 59:343-350(1996).
Liu Y.,et al.Hum. Genet. 103:204-210(1998).
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