|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:64000), IHC-P (5 µg/ml), WB (1-3 µg/ml)|
|Other Names||Galactoside 2-alpha-L-fucosyltransferase 2, 220.127.116.11, Alpha(1, 2)FT 2, Fucosyltransferase 2, GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2, SE2, Secretor blood group alpha-2-fucosyltransferase, Secretor factor, Se, FUT2, SEC2|
|Target/Specificity||Human FUT2 / SE. Reported variants represent identical protein: NP_001091107.1, NP_000502.4|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||FUT2 / SE Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids (PubMed:7876235). The resulting epitope plays a role in cell-cell interaction including host-microbe interaction (PubMed:12692541, PubMed:8018146). Mediates interaction with intestinal microbiota influencing its composition (PubMed:21625510, PubMed:24733310, PubMed:22068912). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235).|
|Cellular Location||Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi|
|Tissue Location||Small intestine, colon and lung.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values.
Kelly R.J.,et al.J. Biol. Chem. 270:4640-4649(1995).
Kudo T.,et al.J. Biol. Chem. 271:9830-9837(1996).
Koda Y.,et al.Eur. J. Biochem. 246:750-755(1997).
Koda Y.,et al.Am. J. Hum. Genet. 59:343-350(1996).
Liu Y.,et al.Hum. Genet. 103:204-210(1998).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.