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CNTN1 / gp135 / Contactin 1 Antibody (aa313-324)

Goat Polyclonal Antibody

     
  • WB - CNTN1 / gp135 / Contactin 1 Antibody (aa313-324) ALS16152
    CNTN1 antibody (0.3 ug/ml) staining of Human Cerebellum (A), Mouse Brain (B) and Rat Brain (C)...
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  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q12860
Reactivity Human, Mouse, Rat, Monkey, Pig, Guinea Pig
Host Goat
Clonality Polyclonal
Calculated MW 113kDa
Dilution ELISA (1:32000), IHC-P (5 µg/ml), WB (0.3-1 µg/ml)
Additional Information
Gene ID 1272
Other Names Contactin-1, Glycoprotein gp135, Neural cell surface protein F3, CNTN1
Target/Specificity Human CNTN1 / gp135 / Contactin 1. This antibody is expected to recognize all reported isoforms (NP_001834.2; NP_778203.1; NP_001242992.1). Reported variants represent identical protein: NP_001242993.1, NP_001242992.1.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsCNTN1 / gp135 / Contactin 1 Antibody (aa313-324) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CNTN1
Function Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).
Cellular Location Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side
Tissue Location Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle
Research Areas
Citations (0)

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Background

Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).

References

Reid R.A.,et al.Brain Res. Mol. Brain Res. 21:1-8(1994).
Berglund E.O.,et al.Genomics 21:571-582(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Berglund E.,et al.Eur. J. Biochem. 197:549-554(1991).
Liu T.,et al.J. Proteome Res. 4:2070-2080(2005).

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$ 395.00
Cat# ALS16152
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