|Application ||WB, IHC-P, E|
|Reactivity||Human, Rabbit, Monkey, Pig, Bovine|
|Dilution||ELISA (1:128000), IHC-P (5 µg/ml), WB (0.1-0.3 µg/ml)|
|Other Names||Disintegrin and metalloproteinase domain-containing protein 19, ADAM 19, 3.4.24.-, Meltrin-beta, Metalloprotease and disintegrin dendritic antigen marker, MADDAM, ADAM19, MLTNB|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||ADAM19 Antibody (aa574-588) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in many normal organ tissues and several cancer cell lines|
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Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).
Wang Y.-G.,et al.Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
Fritsche J.,et al.Blood 96:732-739(2000).
Wei P.,et al.Biochem. Biophys. Res. Commun. 280:744-755(2001).
Schmutz J.,et al.Nature 431:268-274(2004).
Xu R.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
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