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>   home   >   Products   >   Primary Antibodies   >   HNRNPA2B1 Antibody (aa127-137)   

HNRNPA2B1 Antibody (aa127-137)

Goat Polyclonal Antibody

     
  • WB - HNRNPA2B1 Antibody (aa127-137) ALS16161
    HNRNPA2B1 antibody (0.3 ug/ml) staining of MCF7 lysate (35 ug protein in RIPA buffer).
  • IHC - HNRNPA2B1 Antibody (aa127-137) ALS16161
    Anti-HNRNPA2B1 antibody IHC staining of human small intestine.
  • IHC - HNRNPA2B1 Antibody (aa127-137) ALS16161
    Anti-HNRNPA2B1 antibody IHC staining of human testis.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P22626
Reactivity Human, Mouse, Rat, Rabbit, Monkey, Pig, Chicken, Horse, Bovine
Host Goat
Clonality Polyclonal
Calculated MW 37kDa
Dilution ELISA (1:64000), IHC-P (5 µg/ml), WB (1-3 µg/ml)
Additional Information
Gene ID 3181
Other Names Heterogeneous nuclear ribonucleoproteins A2/B1, hnRNP A2/B1, HNRNPA2B1, HNRPA2B1
Target/Specificity Human HNRNPA2B1. This antibody is expected to recognize both reported isoforms (NP_002128.1; NP_112533.1).
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsHNRNPA2B1 Antibody (aa127-137) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HNRNPA2B1
Synonyms HNRPA2B1
Function Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non- random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri- miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A- containing pre-mRNAs (PubMed:26321680).
Cellular Location Nucleus, nucleoplasm. Cytoplasmic granule Secreted, exosome. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661). Component of ribonucleosomes (PubMed:17289661) Not found in the nucleolus (PubMed:17289661). Found in exosomes follwong sumoylation (PubMed:24356509)
Citations (0)

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Background

Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus.

References

Burd C.G.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:9788-9792(1989).
Biamonti G.,et al.Nucleic Acids Res. 22:1996-2002(1994).
Kozu T.,et al.Genomics 25:365-371(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bienvenut W.V.,et al.Submitted (JUN-2009) to UniProtKB.

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$ 395.00
Cat# ALS16161
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