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TPMT Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P51580 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 28kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 7172 |
|---|---|
| Other Names | Thiopurine S-methyltransferase, 2.1.1.67, Thiopurine methyltransferase, TPMT |
| Target/Specificity | Human TPMT |
| Reconstitution & Storage | Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles. |
| Precautions | TPMT Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TPMT |
|---|---|
| Function | Catalyzes the S-methylation of thiopurine drugs such as 6- mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S- adenosyl-L-methionine as the methyl donor (PubMed:657528, PubMed:18484748). TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified. |
| Cellular Location | Cytoplasm. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine.
References
Honchel R.,et al.Mol. Pharmacol. 43:878-887(1993).
Lee D.,et al.Drug Metab. Dispos. 23:398-405(1995).
Szumlanski C.,et al.DNA Cell Biol. 15:17-30(1996).
Krynetski E.Y.,et al.Pharm. Res. 14:1672-1678(1997).
Otterness D.,et al.Clin. Pharmacol. Ther. 62:60-73(1997).
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