|Application ||WB, IHC-P|
|Dilution||IHC-P (7.5 µg/ml), WB (1:500-1:3000),|
|Other Names||L-xylulose reductase, XR, 22.214.171.124, Carbonyl reductase II, Dicarbonyl/L-xylulose reductase, Kidney dicarbonyl reductase, kiDCR, Short chain dehydrogenase/reductase family 20C member 1, Sperm surface protein P34H, DCXR, SDR20C1|
|Reconstitution & Storage||Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.|
|Precautions||DCXR Antibody (aa182-244) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.|
|Cellular Location||Membrane; Peripheral membrane protein. Note=Probably recruited to membranes via an interaction with phosphatidylinositol.|
|Tissue Location||Highly expressed in kidney, liver and epididymis. In the epididymis, it is mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis|
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Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
Legare C.,et al.Endocrinology 140:3318-3327(1999).
Nakagawa J.,et al.J. Biol. Chem. 277:17883-17891(2002).
Xia X.Y.,et al.Zhonghua Nan Ke Xue 9:24-27(2003).
Huang C.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Liu Q.,et al.Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
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