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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Angiogenin / ANG Antibody (aa176-224)   

Angiogenin / ANG Antibody (aa176-224)

Rabbit Polyclonal Antibody

     
  • WB - Angiogenin / ANG Antibody (aa176-224) ALS16232
    Western blot of p-CD318 (Y707) pAb in extracts from HeLa cells.
  • IHC - Angiogenin / ANG Antibody (aa176-224) ALS16232
    Anti-Angiogenin / ANG antibody IHC staining of human liver.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P03950
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 17kDa
Dilution IHC-P (10 µg/ml), WB (1:500-1:1000),
Additional Information
Gene ID 283
Other Names Angiogenin, 3.1.27.-, Ribonuclease 5, RNase 5, ANG, RNASE5
Target/Specificity Human Angiogenin / ANG
Reconstitution & Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PrecautionsAngiogenin / ANG Antibody (aa176-224) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ANG
Synonyms RNASE5
Function Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
Cellular Location Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000250|UniProtKB:Q3TMQ6}. Secreted {ECO:0000250|UniProtKB:P10152}. Nucleus Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (PubMed:12051708).
Tissue Location Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons
Volume 50 µl
Research Areas
Citations (0)

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Background

Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.

References

Kurachi K.,et al.Biochemistry 24:5494-5499(1985).
Zhang J.,et al.Mol. Biol. Evol. 19:438-445(2002).
Li J.,et al.Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
Ebert L.,et al.Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
Wakamatsu A.,et al.Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS16232
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