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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   ANK2 / Ankyrin B Antibody (aa203-496, clone S105-17)   

ANK2 / Ankyrin B Antibody (aa203-496, clone S105-17)

Mouse Monoclonal Antibody

     
  • IHC - ANK2 / Ankyrin B Antibody (aa203-496, clone S105-17) ALS16238
    Anti-ANK2 / Ankyrin B antibody IHC staining of human prostate.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC
Primary Accession Q01484
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Clone Names S105-17
Calculated MW 434kDa
Dilution IHC-P (10 µg/ml), WB (1 µg/ml),
Additional Information
Gene ID 287
Other Names Ankyrin-2, ANK-2, Ankyrin-B, Brain ankyrin, Non-erythroid ankyrin, ANK2
Target/Specificity Detects ~>200kD. No cross-reactivity against Ankyrin-G.
Reconstitution & Storage Store at -20°C.
PrecautionsANK2 / Ankyrin B Antibody (aa203-496, clone S105-17) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ANK2
Function In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions (By similarity). Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner segment of rod photoreceptors. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate.
Cellular Location Cytoplasm, cytoskeleton. Membrane. Cytoplasm, myofibril, sarcomere, M line. Apical cell membrane. Cell membrane. Cell junction, synapse, postsynaptic cell membrane. Note=Expressed at the apical membrane of airway lung epithelial cells (By similarity) Localized to the plasma membrane of the inner segments of photoreceptors in retina. Colocalizes with SPTBN1 in a distict intracellular compartment of neonatal cardiomyocytes (By similarity). In skeletal muscle, localizes to neuromuscular junctions (By similarity).
Tissue Location Present in plasma membrane of neurons as well as glial cells throughout the brain. Expressed in fetal brain and in temporal cortex of adult brain. Also expressed in the inner segments of rod photoreceptors in retina
Research Areas
Citations (0)

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Background

In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions (By similarity). Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner segment of rod photoreceptors. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate.

References

Otto E.,et al.J. Cell Biol. 114:241-253(1991).
Carpenter S.,et al.Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
Chan W.,et al.J. Cell Biol. 123:1463-1473(1993).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Hillier L.W.,et al.Nature 434:724-731(2005).

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$ 395.00
Cat# ALS16238
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