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MED24 / TRAP100 Antibody (aa801-850)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IHC-P, IF |
|---|---|
| Primary Accession | O75448 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 110kDa |
| Dilution | IF (1:50-1:200), IHC (1:50-1:200), IHC-P (5 µg/ml), WB (1:500-1:1000) , |
| Gene ID | 9862 |
|---|---|
| Other Names | Mediator of RNA polymerase II transcription subunit 24, Activator-recruited cofactor 100 kDa component, ARC100, Cofactor required for Sp1 transcriptional activation subunit 4, CRSP complex subunit 4, Mediator complex subunit 24, Thyroid hormone receptor-associated protein 4, Thyroid hormone receptor-associated protein complex 100 kDa component, Trap100, hTRAP100, Vitamin D3 receptor-interacting protein complex 100 kDa component, DRIP100, MED24 |
| Target/Specificity | Human TRAP100 / MED24 |
| Reconstitution & Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Precautions | MED24 / TRAP100 Antibody (aa801-850) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MED24 |
|---|---|
| Synonyms | ARC100, CRSP4, DRIP100, KIAA0130, THRAP4 |
| Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. |
| Cellular Location | Nucleus. |
| Tissue Location | Ubiquitous. Abundant in skeletal muscle, heart and placenta. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
References
Yuan C.-X.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:7939-7944(1998).
Rachez C.,et al.Genes Dev. 12:1787-1800(1998).
Nagase T.,et al.DNA Res. 2:167-174(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
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