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DPP9 Antibody (clone 6A12)

Mouse Monoclonal Antibody

     
  • WB - DPP9 Antibody (clone 6A12) ALS16278
    Western blot of extracts (35 ug) from 9 different cell lines by using anti-DPP9 monoclonal antibody.
    detail
  • IHC - DPP9 Antibody (clone 6A12) ALS16278
    Anti-DPP9 antibody IHC staining of human kidney.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, Flo
Primary Accession Q86TI2
Reactivity Human, Dog
Host Mouse
Clonality Monoclonal
Clone Names 6A12
Calculated MW 98kDa
Dilution Flo (1:100), IHC-P (10 µg/ml), WB (1:500-1:2000)
Additional Information
Gene ID 91039
Other Names Dipeptidyl peptidase 9, DP9, 3.4.14.5, Dipeptidyl peptidase IV-related protein 2, DPRP-2, Dipeptidyl peptidase IX, DPP IX, Dipeptidyl peptidase-like protein 9, DPLP9, DPP9, DPRP2
Target/Specificity Human DPP9
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsDPP9 Antibody (clone 6A12) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DPP9 {ECO:0000303|PubMed:12459266, ECO:0000312|HGNC:HGNC:18648}
Function Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:12662155, PubMed:16475979, PubMed:19667070, PubMed:29382749, PubMed:30291141, PubMed:33731929, PubMed:36112693). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29967349, PubMed:30291141, PubMed:31525884, PubMed:32796818, PubMed:36357533, PubMed:36112693). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (PubMed:34019797, PubMed:33731929, PubMed:33731932). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP9, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (PubMed:33731929).
Cellular Location [Isoform 1]: Cytoplasm, cytosol
Tissue Location Ubiquitously expressed, with highest levels in liver, heart and muscle, and lowest levels in brain
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2.

References

Olsen C.,et al.Gene 299:185-193(2002).
Qi S.Y.,et al.Biochem. J. 373:179-189(2003).
Ajami K.,et al.Biochim. Biophys. Acta 1679:18-28(2004).
Bjelke J.R.,et al.Biochem. J. 396:391-399(2006).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 467.50
Cat# ALS16278
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