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CASP1 / Caspase 1 Antibody (FITC)

Rabbit Polyclonal Antibody

     
  • IHC - CASP1 / Caspase 1 Antibody (FITC) ALS16280
    Anti-CASP1 / Caspase 1 antibody IHC staining of human testis.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P29466
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 45kDa
Dilution IHC-P (1:100)
Additional Information
Gene ID 834
Other Names Caspase-1, CASP-1, 3.4.22.36, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, ICE, IL-1 beta-converting enzyme, p45, Caspase-1 subunit p20, Caspase-1 subunit p10, CASP1, IL1BC, IL1BCE
Target/Specificity Human CASP1 / Caspase 1
Reconstitution & Storage Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
PrecautionsCASP1 / Caspase 1 Antibody (FITC) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CASP1
Synonyms IL1BC, IL1BCE
Function Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
Cellular Location Cytoplasm.
Tissue Location Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
Research Areas
Citations (0)

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Background

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.

References

Thornberry N.A.,et al.Nature 356:768-774(1992).
Cerretti D.P.,et al.Science 256:97-100(1992).
Alnemri E.S.,et al.J. Biol. Chem. 270:4312-4317(1995).
Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Taylor T.D.,et al.Nature 440:497-500(2006).

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$ 395.00
Cat# ALS16280
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