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ITGA7 / Integrin Alpha 7 Antibody (clone 3C12)

Mouse Monoclonal Antibody

     
  • IHC - ITGA7  / Integrin Alpha 7 Antibody (clone 3C12) ALS16305
    Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, ICC, Flo
Primary Accession Q13683
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Clone Names 3C12
Calculated MW 129kDa
Dilution Flo (10-20 µg/ml), ICC (10 µg/ml), IHC-P (10 µg/ml)
Additional Information
Gene ID 3679
Other Names Integrin alpha-7, Integrin alpha-7 heavy chain, Integrin alpha-7 light chain, Integrin alpha-7 70 kDa form, ITGA7
Target/Specificity Mouse ITGA7
Reconstitution & Storage Store at -20°C.
PrecautionsITGA7 / Integrin Alpha 7 Antibody (clone 3C12) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ITGA7
Function Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Isoforms containing segment A are predominantly expressed in skeletal muscle. Isoforms containing segment B are abundantly expressed in skeletal muscle, moderately in cardiac muscle, small intestine, colon, ovary and prostate and weakly in lung and testes. Isoforms containing segment X2D are expressed at low levels in fetal and adult skeletal muscle and in cardiac muscle, but are not detected in myoblasts and myotubes. In muscle fibers isoforms containing segment A and B are expressed at myotendinous and neuromuscular junctions; isoforms containing segment C are expressed at neuromuscular junctions and at extrasynaptic sites. Isoforms containing segments X1 or X2 or, at low levels, X1X2 are expressed in fetal and adult skeletal muscle (myoblasts and myotubes) and cardiac muscle
Research Areas
Citations (0)

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Background

Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.

References

Leung E.,et al.Biochem. Biophys. Res. Commun. 243:317-325(1998).
Hayashi Y.K.,et al.Nat. Genet. 19:94-97(1998).
Vizirianakis I.S.,et al.Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
Vignier N.,et al.Biochem. Biophys. Res. Commun. 260:357-364(1999).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).

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$ 395.00
Cat# ALS16305
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