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>   home   >   Products   >   Primary Antibodies   >   SF3B1 Antibody (aa75-124)   

SF3B1 Antibody (aa75-124)

Rabbit Polyclonal Antibody

     
  • WB - SF3B1 Antibody (aa75-124) ALS16345
    Western blot of extracts from Jurkat cells, using SAP 155 antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O75533
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 146kDa
Dilution ELISA (1:10000), IHC-P (20 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 23451
Other Names Splicing factor 3B subunit 1, Pre-mRNA-splicing factor SF3b 155 kDa subunit, SF3b155, Spliceosome-associated protein 155, SAP 155, SF3B1, SAP155
Target/Specificity SAP 155 antibody detects endogenous levels of SAP 155.
Reconstitution & Storage Store at -20°C.
PrecautionsSF3B1 Antibody (aa75-124) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SF3B1
Synonyms SAP155
Function Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
Cellular Location Nucleus speckle. Note=During mitosis, transiently dispersed from the nuclear speckles to the cytoplasm
Volume 50 µl
Citations (0)

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Background

Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.

References

Wang C.,et al.Genes Dev. 12:1409-1414(1998).
Woessner J.,et al.Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
Yu W.,et al.Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
Das R.,et al.Mol. Cell 5:779-787(2000).

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$ 395.00
Cat# ALS16345
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