|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (5 µg/ml)|
|Other Names||Sodium channel subunit beta-1, SCN1B|
|Target/Specificity||Human, mouse, rat. No cross reactivity with other proteins.|
|Reconstitution & Storage||Short term +4°C; Long term -20°C|
|Precautions||SCN1B Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||The overall expression of isoforms 1 and 2 is very similar. Isoform 1 is abundantly expressed in skeletal muscle, heart and brain. Isoform 2 is highly expressed in brain and skeletal muscle and present at a very low level in heart, placenta, lung, liver, kidney and pancreas. In brain, isoform 2 is most abundant in the cerebellum, followed by the cerebral cortex and occipital lobe, while isoform 1 levels are higher in the cortex compared to the cerebellum. Isoform 2 is expressed in many regions of the brain, including cerebellar Purkinje cells, cortex pyramidal neurons and many of the neuronal fibers throughout the brain (at protein level). Also detected in dorsal root ganglion, in fibers of the spinal nerve and in cortical neurons and their processes (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.
McClatchey A.I.,et al.Hum. Mol. Genet. 2:745-749(1993).
Makita N.,et al.J. Biol. Chem. 269:7571-7578(1994).
Makita N.,et al.Genomics 23:628-634(1994).
Qin N.,et al.Eur. J. Biochem. 270:4762-4770(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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