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SCN1B Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - SCN1B Antibody (N-Terminus) ALS16369
    Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q07699
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 25kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 6324
Other Names Sodium channel subunit beta-1, SCN1B
Target/Specificity Human, mouse, rat. No cross reactivity with other proteins.
Reconstitution & Storage Short term +4°C; Long term -20°C
PrecautionsSCN1B Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SCN1B
Function Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.
Cellular Location Isoform 1: Cell membrane; Single- pass type I membrane protein {ECO:0000255, ECO:0000305|PubMed:8125980}
Tissue Location The overall expression of isoforms 1 and 2 is very similar. Isoform 1 is abundantly expressed in skeletal muscle, heart and brain. Isoform 2 is highly expressed in brain and skeletal muscle and present at a very low level in heart, placenta, lung, liver, kidney and pancreas. In brain, isoform 2 is most abundant in the cerebellum, followed by the cerebral cortex and occipital lobe, while isoform 1 levels are higher in the cortex compared to the cerebellum. Isoform 2 is expressed in many regions of the brain, including cerebellar Purkinje cells, cortex pyramidal neurons and many of the neuronal fibers throughout the brain (at protein level). Also detected in dorsal root ganglion, in fibers of the spinal nerve and in cortical neurons and their processes (at protein level).
Volume 50 µl
Research Areas
Citations (0)

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Background

Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

References

McClatchey A.I.,et al.Hum. Mol. Genet. 2:745-749(1993).
Makita N.,et al.J. Biol. Chem. 269:7571-7578(1994).
Makita N.,et al.Genomics 23:628-634(1994).
Qin N.,et al.Eur. J. Biochem. 270:4762-4770(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS16369
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