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>   home   >   Products   >   Primary Antibodies   >   DENR / Density Regulated Antibody (aa148-198)   

DENR / Density Regulated Antibody (aa148-198)

Rabbit Polyclonal Antibody

     
  • IHC - DENR / Density Regulated Antibody (aa148-198) ALS16373
    Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession O43583
Reactivity Human, Mouse, Rat, Chicken, Goat, Xenopus, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 22kDa
Dilution IHC-P (5 µg/ml), WB (1:2000-1:10000),
Additional Information
Gene ID 8562
Other Names Density-regulated protein, DRP, Protein DRP1, Smooth muscle cell-associated protein 3, SMAP-3, DENR, DRP1
Target/Specificity Region between residue 148 and 198 of human Density-Regulated Protein using the numbering given in entry NP_003668.2 (GeneID 8562).
Reconstitution & Storage Store at 2-8°C for up to 1 year.
PrecautionsDENR / Density Regulated Antibody (aa148-198) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DENR
Synonyms DRP1
Function May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.
Tissue Location Highly expressed in heart and skeletal muscle and moderately expressed in the brain, placenta, liver and pancreas. Weakly expressed in the lung and kidney
Volume 50 µl
Citations (0)

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Background

May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.

References

Deyo J.E.,et al.DNA Cell Biol. 17:437-447(1998).
Nishimoto S.,et al.Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
Scherer S.E.,et al.Nature 440:346-351(2006).
Oh J.J.,et al.Nucleic Acids Res. 27:4008-4017(1999).
Reinert L.S.,et al.Cancer Res. 66:8994-9001(2006).

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$ 395.00
Cat# ALS16373
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