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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SPON2 / MINDIN Antibody (aa55-104)   

SPON2 / MINDIN Antibody (aa55-104)

Rabbit Polyclonal Antibody

     
  • WB - SPON2 / MINDIN Antibody (aa55-104) ALS16391
    Western blot of the lysates from HUVEC cells using SPON2 antibody.
  • IHC - SPON2 / MINDIN Antibody (aa55-104) ALS16391
    Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9BUD6
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 36kDa
Dilution ELISA (1:10000), IHC-P (5 µg/ml), WB (1:500-1:1000)
Additional Information
Other Names Spondin-2, Differentially expressed in cancerous and non-cancerous lung cells 1, DIL-1, Mindin, SPON2, DIL1
Target/Specificity SPON2 Antibodyantibody detects endogenous levels of SPON2.
Reconstitution & Storage Store at -20°C.
PrecautionsSPON2 / MINDIN Antibody (aa55-104) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPON2
Synonyms DIL1
Function Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern- recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS).
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Expressed in normal lung tissue but not in lung carcinoma cell lines. EMBL; AB027466; BAA85892.1; -; mRNA EMBL; AY358948; AAQ89307.1; -; mRNA EMBL; AK074618; BAC11092.1; -; mRNA EMBL; AK074770; BAC11196.1; -; mRNA EMBL; AC092535; AAY40988.1; -; Genomic_DNA EMBL; CH471131; EAW82604.1; -; Genomic_DNA EMBL; CH471131; EAW82606.1; -; Genomic_DNA EMBL; BC002707; AAH02707.1; -; mRNA EMBL; BC036341; AAH36341.1; -; mRNA CCDS; CCDS3347.1; - RefSeq; NP_001121797.1; NM_001128325.2 RefSeq; NP_001185950.1; NM_001199021.1 RefSeq; NP_036577.1; NM_012445.3 UniGene; Hs.302963; - UniGene; Hs.635350; - UniGene; Hs.736956; - PDB; 3D34; X-ray; 1.80 A; A/B=27-249 PDBsum; 3D34; - ProteinModelPortal; Q9BUD6; - SMR; Q9BUD6; - BioGrid; 115686; 1 IntAct; Q9BUD6; 2 STRING; 9606.ENSP00000290902; - iPTMnet; Q9BUD6; - PhosphoSitePlus; Q9BUD6; - BioMuta; SPON2; - DMDM; 313104285; - MaxQB; Q9BUD6; - PaxDb; Q9BUD6; - PeptideAtlas; Q9BUD6; - PRIDE; Q9BUD6; - ProteomicsDB; 79078; - Ensembl; ENST00000290902; ENSP00000290902; ENSG00000159674 Ensembl; ENST00000431380; ENSP00000394832; ENSG00000159674 Ensembl; ENST00000617421; ENSP00000483599; ENSG00000159674 GeneID; 10417; - KEGG; hsa:10417; - UCSC; uc003gco.5; human CTD; 10417; - DisGeNET; 10417; - EuPathDB; HostDB:ENSG00000159674.11; - GeneCards; SPON2; - HGNC; HGNC:11253; SPON2 HPA; HPA040170; - HPA; HPA066095; - MIM; 605918; gene neXtProt; NX_Q9BUD6; - PharmGKB; PA36083; - eggNOG; ENOG410IR0P; Eukaryota eggNOG; ENOG410XX1S; LUCA HOGENOM; HOG000114626; - HOVERGEN; HBG052919; - InParanoid; Q9BUD6; - OrthoDB; EOG091G0BT5; - PhylomeDB; Q9BUD6; - TreeFam; TF326913; - Reactome; R-HSA-5083635; Defective B3GALTL causes Peters-plus syndrome (PpS) Reactome; R-HSA-5173214; O-glycosylation of TSR domain-containing proteins ChiTaRS; SPON2; human EvolutionaryTrace; Q9BUD6; - GenomeRNAi; 10417; - PRO; PR:Q9BUD6; - Proteomes; UP000005640; Chromosome 4 Bgee; ENSG00000159674; - CleanEx; HS_SPON2; - ExpressionAtlas; Q9BUD6; baseline and differential Genevisible; Q9BUD6; HS GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB GO; GO:0031012; C:extracellular matrix; IEA:Ensembl GO; GO:0003823; F:antigen binding; IEA:Ensembl GO; GO:0001530; F:lipopolysaccharide binding; IEA:Ensembl GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW GO; GO:0007411; P:axon guidance; TAS:ProtInc GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl GO; GO:0050832; P:defense response to fungus; IEA:Ensembl GO; GO:0051607; P:defense response to virus; IEA:Ensembl GO; GO:0043152; P:induction of bacterial agglutination; IEA:Ensembl GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW GO; GO:0002448; P:mast cell mediated immunity; IEA:Ensembl GO; GO:0008228; P:opsonization; IEA:Ensembl GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl GO; GO:0060907; P:positive regulation of macrophage cytokine production; IEA:Ensembl GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl Gene3D; 2.20.100.10; -; 1 Gene3D; 2.60.40.2130; -; 1 InterPro; IPR009465; Spondin_N InterPro; IPR038678; Spondin_N_sf InterPro; IPR000884; TSP1_rpt InterPro; IPR036383; TSP1_rpt_sf Pfam; PF06468; Spond_N; 1 Pfam; PF00090; TSP_1; 1 SMART; SM00209; TSP1; 1 SUPFAM; SSF82895; SSF82895; 1 PROSITE; PS51020; SPONDIN; 1 PROSITE; PS50092; TSP1; 1 1: Evidence at protein level; 3D-structure; Calcium; Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; Extracellular matrix; Glycoprotein; Immunity; Innate immunity; Metal-binding; Polymorphism; Reference proteome; Secreted; Signal SIGNAL 1 26 CHAIN 27 331 Spondin-2 /FTId=PRO_0000035870 DOMAIN 31 221 Spondin. {ECO:0000255|PROSITE- ProRule:PRU00364} DOMAIN 277 331 TSP type-1. {ECO:0000255|PROSITE- ProRule:PRU00210} METAL 42 42 Divalent metal cation. METAL 122 122 Divalent metal cation. METAL 141 141 Divalent metal cation. METAL 160 160 Calcium. {ECO:0000244|PDB:3D34, ECO:0000269|PubMed:19153605} METAL 188 188 Calcium. {ECO:0000244|PDB:3D34, ECO:0000269|PubMed:19153605} METAL 192 192 Calcium; via carbonyl oxygen {ECO:0000244|PDB:3D34, ECO:0000269|PubMed:19153605} SITE 141 141 Important for metal ion-dependent interaction with integrin CARBOHYD 283 283 C-linked (Man) tryptophan DISULFID 35 171 {ECO:0000255|PROSITE-ProRule:PRU00210, ECO:0000269|PubMed:19153605} VARIANT 38 38 R -> G (in dbSNP:rs6836335) /FTId=VAR_055149 VARIANT 40 40 L -> P (in dbSNP:rs922697) {ECO:0000269|PubMed:10512675, ECO:0000269|PubMed:12975309, ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334, ECO:0000269|Ref.5} /FTId=VAR_019701 VARIANT 122 122 E -> A (in dbSNP:rs11247975) {ECO:0000269|PubMed:10512675, ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15815621, ECO:0000269|Ref.5} /FTId=VAR_019702 VARIANT 242 242 V -> L (in dbSNP:rs2279279) {ECO:0000269|PubMed:12975309, ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334, ECO:0000269|Ref.5} /FTId=VAR_019703 MUTAGEN 122 122 E->A: Strongly reduced metal-dependent interaction with integrin; when associated with A-141 MUTAGEN 141 141 E->A: Strongly reduced metal-dependent interaction with integrin; when associated with A-122 STRAND 41 49 {ECO:0000244|PDB:3D34} TURN 53 55 {ECO:0000244|PDB:3D34} STRAND 63 65 {ECO:0000244|PDB:3D34} STRAND 67 77 {ECO:0000244|PDB:3D34} HELIX 92 100 {ECO:0000244|PDB:3D34} HELIX 104 117 {ECO:0000244|PDB:3D34} STRAND 120 126 {ECO:0000244|PDB:3D34} STRAND 129 131 {ECO:0000244|PDB:3D34} STRAND 135 143 {ECO:0000244|PDB:3D34} STRAND 148 157 {ECO:0000244|PDB:3D34} STRAND 159 169 {ECO:0000244|PDB:3D34} STRAND 178 184 {ECO:0000244|PDB:3D34} STRAND 190 192 {ECO:0000244|PDB:3D34} STRAND 215 218 {ECO:0000244|PDB:3D34} STRAND 230 232 {ECO:0000244|PDB:3D34} STRAND 236 243 {ECO:0000244|PDB:3D34} SEQUENCE 331 AA; 35846 MW; 8AF827142D921705 CRC64; MENPSPAAAL GKALCALLLA TLGAAGQPLG GESICSARAL AKYSITFTGK WSQTAFPKQY PLFRPPAQWS SLLGAAHSSD YSMWRKNQYV SNGLRDFAER GEAWALMKEI EAAGEALQSV HEVFSAPAVP SGTGQTSAEL EVQRRHSLVS FVVRIVPSPD WFVGVDSLDL CDGDRWREQA ALDLYPYDAG TDSGFTFSSP NFATIPQDTV TEITSSSPSH PANSFYYPRL KALPPIARVT LVRLRQSPRA FIPPAPVLPS RDNEIVDSAS VPETPLDCEV SLWSSWGLCG GHCGRLGTKS RTRYVRVQPA NNGSPCPELE EEAECVPDNC V
Volume 50 µl
Research Areas
Citations (0)

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Background

Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern- recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS).

References

Manda R.,et al.Genomics 61:5-14(1999).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 425.00
Cat# ALS16391
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