|Application ||WB, IHC, IHC-P|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC (1:50-1:200), IHC-P (5 µg/ml), WB (1:500-1:1000)|
|Other Names||Guanine nucleotide-binding protein G(olf) subunit alpha, Adenylate cyclase-stimulating G alpha protein, olfactory type, GNAL|
|Reconstitution & Storage||Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.|
|Precautions||GNAL Antibody (aa50-100) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters.|
|Tissue Location||Detected in olfactory neuroepithelium, brain, testis, and to a lower extent in retina, lung alveoli, spleen Trace amounts where seen in kidney, adrenal gland and liver. Found to be expressed in all the insulinomas examined|
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Provided below are standard protocols that you may find useful for product applications.
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters.
Zigman J.M.,et al.Endocrinology 133:2508-2514(1993).
Vuoristo J.T.,et al.Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 437:551-555(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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