|Application ||WB, IHC-P, IF, Flo|
|Dilution||Flo (1:100), IF (1:100), IHC-P (10 µg/ml), WB (1:2000) ,|
|Other Names||GTPase IMAP family member 4, Immunity-associated nucleotide 1 protein, IAN-1, hIAN1, Immunity-associated protein 4, GIMAP4, IAN1, IMAP4|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||GIMAP4 Antibody (clone 1C6) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in regulating lymphocyte apoptosis (By similarity). Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium.|
|Cellular Location||Cytoplasm, cytosol|
|Tissue Location||Highly expressed in spleen and peripheral blood leukocytes that contain mostly T- and B-lymphocytes Expressed specifically in resting T- and B-lymphocytes and expression significantly decreases during B- or T-lymphocyte activation. Expressed at lower levels in thymus, ovary, colon and small intestine.|
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May play a role in regulating lymphocyte apoptosis (By similarity). Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium.
Cambot M.,et al.Blood 99:3293-3301(2002).
Liu Y.Q.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schwefel D.,et al.Structure 21:550-559(2013).
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