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P2RX7 / P2X7 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - P2RX7 / P2X7 Antibody (C-Terminus) ALS16429
    Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IF - P2RX7 / P2X7 Antibody (C-Terminus) ALS16429
    Immunofluorescence of P2RX7 in 3T3 cells with P2RX7 antibody at 20 ug/mL.
  • ICC - P2RX7 / P2X7 Antibody (C-Terminus) ALS16429
    Immunocytochemistry of P2RX7 in 3T3 cells with P2RX7 antibody at 5 ug/mL.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC, E
Primary Accession Q99572
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 69kDa
Dilution ICC (5 µg/ml), IF (20 µg/ml), IHC-P (5 µg/ml), WB (1-2 µg/ml) ,
Additional Information
Gene ID 5027
Other Names P2X purinoceptor 7, P2X7, ATP receptor, P2Z receptor, Purinergic receptor, P2RX7
Target/Specificity P2RX7 antibody is human, mouse, and rat reactive. Multiple isoforms of P2RX7 are known to exist.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsP2RX7 / P2X7 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name P2RX7
Function Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Widely expressed with highest levels in brain and immune tissues.
Research Areas
Citations (0)

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Background

Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.

References

Rassendren F.,et al.J. Biol. Chem. 272:5482-5486(1997).
Buell G.N.,et al.Recept. Channels 5:347-354(1998).
Cheewatrakoolpong B.,et al.Biochem. Biophys. Res. Commun. 332:17-27(2005).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).

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$ 395.00
Cat# ALS16429
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