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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   C2CD3 Antibody (Internal)   

C2CD3 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - C2CD3 Antibody (Internal) ALS16457
    Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IHC - C2CD3 Antibody (Internal) ALS16457
    Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q4AC94
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 260kDa
Dilution IHC-P (10 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 26005
Other Names C2 domain-containing protein 3, C2CD3
Target/Specificity C2CD3 antibody is human, mouse and rat reactive.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsC2CD3 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name C2CD3
Function Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3.
Cellular Location Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to centrioles and procentrioles both in interphase and mitosis. Localizes to centriolar satellites, localization is dependent on PCM1 and dynein-mediated retrograde transport. Also localizes to the distal ends of the mother and daughter centrioles
Research Areas
Citations (0)

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Background

Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3.

References

Totoki Y.,et al.Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
Taylor T.D.,et al.Nature 440:497-500(2006).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Liu T.,et al.J. Proteome Res. 4:2070-2080(2005).

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$ 395.00
Cat# ALS16457
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