|Application ||WB, IHC-P, ICC, IHC-Fr, Flo|
|Reactivity||Human, Rabbit, Monkey|
|Calculated MW||83618 Da|
|Dilution||Flo (1:25 - 1:200), IHC-Fr (1:25 - 1:200), IHC-P (10 µg/ml), WB (1:100 - 1:1000),|
|Other Names||RTN1, Reticulon-1, NSP, Reticulon 1|
|Target/Specificity||Recognizes an epitope located within the region of amino acids 421-589 of the neuro-endocrine specific protein Reticulon-1A (NSP-A), which is also present in the N-terminal part of Reticulon-1B (NSP-B). In normal tissues, antibody reacts with brain P ...|
|Reconstitution & Storage||PBS containing 0.09% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||RTN1 / Reticulon 1 Antibody (clone RNL-2) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression of isoform RTN1-C is strongly correlated with neuronal differentiation|
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May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.
Roebroek A.J.M.,et al.J. Biol. Chem. 268:13439-13447(1993).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Roebroek A.J.M.,et al.Genomics 32:191-199(1996).
Hens J.,et al.Cell Tissue Res. 292:229-237(1998).
Hunter M.,et al.Biochem. Biophys. Res. Commun. 332:982-992(2005).
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