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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   COPS3 Antibody (aa374-423)   

COPS3 Antibody (aa374-423)

Rabbit Polyclonal Antibody

     
  • IHC - COPS3 Antibody (aa374-423) ALS16539
    Anti-COPS3 antibody IHC staining of human breast.
  • IF - COPS3 Antibody (aa374-423) ALS16539
    Immunofluorescence of HeLa cells, using JAB1 Antibody.
  • WB - COPS3 Antibody (aa374-423) ALS16539
    Western blot of extracts from LOVO cells, using JAB1 Antibody.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q9UNS2
Other Accession 8533
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 47873 Da
Dilution ELISA (1:5000), IF (1:100 - 1:500), IHC-P (20 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 8533
Other Names COPS3, COP9 complex subunit 3, SGN3, Signalosome subunit 3
Target/Specificity COPS3 Antibody detects endogenous levels of total COPS3 protein.
Reconstitution & Storage PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.
PrecautionsCOPS3 Antibody (aa374-423) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name COPS3
Synonyms CSN3
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Cellular Location Cytoplasm. Nucleus
Tissue Location Widely expressed. Expressed at high level in heart and skeletal muscle.
Volume 50 µl
Research Areas
Citations (0)

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Background

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

References

Seeger M.,et al.FASEB J. 12:469-478(1998).
Potocki L.,et al.Genomics 57:180-182(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS16539
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