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>   home   >   Products   >   Primary Antibodies   >   Developmental Biology   >   FOXN4 Antibody (aa411-460)   

FOXN4 Antibody (aa411-460)

Rabbit Polyclonal Antibody

     
  • IHC - FOXN4 Antibody (aa411-460) ALS16544
    Anti-FOXN4 antibody IHC staining of human testis.
  • WB - FOXN4 Antibody (aa411-460) ALS16544
    Western blot of extracts from LOVO cells, using FOXN4 Antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q96NZ1
Other Accession 121643
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 55215 Da
Dilution ELISA (1:10000), IHC-P (20 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 121643
Other Names FOXN4, Forkhead box N4, Forkhead box protein N4
Target/Specificity FOXN4 Antibody detects endogenous levels of total FOXN4 protein.
Reconstitution & Storage PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.
PrecautionsFOXN4 Antibody (aa411-460) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOXN4
Function Transcription factor essential for neural and some non- neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4- NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089}
Volume 50 µl
Research Areas
Citations (0)

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Background

Transcription factor essential for neural and some non- neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4- NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development (By similarity).

References

Scherer S.E.,et al.Nature 440:346-351(2006).
Danilova N.,et al.Brain Res. Dev. Brain Res. 153:115-119(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS16544
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