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ATP2A1 / SERCA1 Antibody (aa548-597)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O14983 |
| Other Accession | 487 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 110252 Da |
| Dilution | ELISA (1:10000), IHC-P (10 µg/ml), WB (1:500 - 1:1000), |
| Gene ID | 487 |
|---|---|
| Other Names | ATP2A1, SERCA1, ATP2A, Calcium pump 1, SR Ca(2+)-ATPase 1 |
| Target/Specificity | ATP2A1 Antibody detects endogenous levels of total ATP2A1 protein. |
| Reconstitution & Storage | PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year. |
| Precautions | ATP2A1 / SERCA1 Antibody (aa548-597) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ATP2A1 (HGNC:811) |
|---|---|
| Function | Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity). Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:10914677). |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P04191}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P04191}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:P04191}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P04191} |
| Tissue Location | Skeletal muscle, fast twitch muscle (type II) fibers. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
References
Zhang Y.,et al.Genomics 30:415-424(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Daiho T.,et al.J. Biol. Chem. 276:32771-32778(2001).
Odermatt A.,et al.Hum. Genet. 106:482-491(2000).
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