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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   KSR2 Antibody (Ile694)   

KSR2 Antibody (Ile694)

Rabbit Polyclonal Antibody

     
  • IHC - KSR2 Antibody (Ile694) ALS16559
    Anti-KSR2 antibody IHC staining of human kidney.
  • WB - KSR2 Antibody (Ile694) ALS16559
    Western blot analysis of Ksr2 (I694)antibody in extracts from 293 cells.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q6VAB6
Other Accession 283455
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 107632 Da
Dilution IF (1:50 - 1:200), IHC-P (5 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 283455
Other Names KSR2, Kinase suppressor of ras 2, HKSR2
Target/Specificity Human KSR2
Reconstitution & Storage PBS, pH 7.2, 0.05% sodium azide. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PrecautionsKSR2 Antibody (Ile694) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KSR2
Function Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling. Acts as a negative regulator of MAP3K3- mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein
Tissue Location Mainly expressed in brain and kidney.
Volume 50 µl
Research Areas
Citations (0)

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Background

Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling. Acts as a negative regulator of MAP3K3- mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Channavajhala P.L.,et al.J. Biol. Chem. 278:47089-47097(2003).
Channavajhala P.L.,et al.Biochem. Biophys. Res. Commun. 334:1214-1218(2005).
Brennan D.F.,et al.Nature 472:366-369(2011).

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$ 395.00
Cat# ALS16559
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