|Application ||WB, IHC-P|
|Calculated MW||47584 Da|
|Dilution||IHC-P (5 µg/ml), WB (1:1000),|
|Other Names||BCL3, B-cell CLL/lymphoma 3, B-cell leukemia/lymphoma 3, B-cell lymphoma 3 protein, BCL-3, BCL4, D19S37, Proto-oncogene BCL3|
|Target/Specificity||This Polyclonal antibody is directed against human Bcl 3 protein. The product was purified from serum by protein A chromatography. Expect reactivity with human Bcl 3. Cross-reactivity with Bcl 3 from other sources has not been determined.|
|Reconstitution & Storage||PBS, pH 7.4, 0.02% sodium azide. Store at -20°C for up to one year.|
|Precautions||BCL3 / BCL-3 Antibody (aa2-13) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Ubiquitination via 'Lys- 63'-linked ubiquitin chains is required for nuclear accumulation|
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Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).
Ohno H.,et al.Cell 60:991-997(1990).
McKeithan T.W.,et al.Genomics 24:120-126(1994).
Bours V.,et al.Cell 72:729-739(1993).
Heissmeyer V.,et al.EMBO J. 18:4766-4778(1999).
Dechend R.,et al.Oncogene 18:3316-3323(1999).
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