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VWF / Von Willebrand Factor Antibody (FITC)
Sheep Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IHC-F |
|---|---|
| Primary Accession | P04275 |
| Other Accession | 7450 |
| Reactivity | Human |
| Host | Sheep |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 309265 Da |
| Dilution | IHC-Fr (1:50 - 1:100), IHC-P (1:100), |
| Gene ID | 7450 |
|---|---|
| Other Names | VWF, Coagulation factor VIII VWF, F8VWF, VWD, Von Willebrand factor |
| Target/Specificity | Human von Willebrand factor, a glycoprotein synthesized in endothelial cells and megakaryocytes which circulates in the blood associated with factor VIII in a non-covalent complex |
| Reconstitution & Storage | PBS, pH 7.2, 0.09% sodium azide. Short term 4 C, Long term -20 C, Product is photosensitive and should be protected from light. Avoid freeze-thaw cycles. |
| Precautions | VWF / Von Willebrand Factor Antibody (FITC) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | VWF |
|---|---|
| Synonyms | F8VWF |
| Function | Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. |
| Cellular Location | Secreted. Secreted, extracellular space, extracellular matrix. Note=Localized to storage granules |
| Tissue Location | Plasma. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
References
Bonthron D.,et al.Nucleic Acids Res. 14:7125-7128(1986).
Mancuso D.J.,et al.J. Biol. Chem. 264:19514-19527(1989).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Verweij C.L.,et al.EMBO J. 5:1839-1847(1986).
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