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UBR2 Antibody (Internal)

Goat Polyclonal Antibody

     
  • IHC - UBR2 Antibody (Internal) ALS16594
    Anti-UBR2 antibody IHC staining of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q8IWV8
Other Accession 23304
Reactivity Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Chicken, Bovine, Horse, Dog
Host Goat
Clonality Polyclonal
Calculated MW 200538 Da
Dilution ELISA (1:32000), IHC-P (5 µg/ml),
Additional Information
Gene ID 23304
Other Names UBR2, BA49A4.1, C6orf133, DJ392M17.3, DJ242G1.1, N-recognin-2, KIAA0349, RP3-392M17.3
Target/Specificity Human UBR2.
Reconstitution & Storage Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing.
PrecautionsUBR2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBR2
Synonyms C6orf133, KIAA0349
Function E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
Cellular Location Nucleus. Note=Associated with chromatin during meiosis
Tissue Location Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level).
Research Areas
Citations (0)

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Background

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.

References

Kwak K.S.,et al.Cancer Res. 64:8193-8198(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
Nagase T.,et al.DNA Res. 4:141-150(1997).
Yin J.,et al.Hum. Mol. Genet. 13:2421-2430(2004).

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$ 395.00
Cat# ALS16594
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