|Application ||WB, IHC-P, IF, E|
|Calculated MW||99997 Da|
|Dilution||IF (5 µg/ml), IHC-P (5 µg/ml), WB (1 µg/ml),|
|Other Names||LEMD3, MAN1, LEM domain containing 3|
|Target/Specificity||Human LEMD3. At least three isoforms of LEMD3 are known to exist; this antibody will detect all isoforms. LEMD3 antibody is predicted to not cross-react with LEMD1 and LEMD2|
|Reconstitution & Storage||PBS, 0.02% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||LEMD3 / MAN1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.|
|Cellular Location||Nucleus inner membrane; Multi-pass membrane protein|
|Tissue Location||Heart, brain, placenta, lung, liver and skeletal muscle|
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Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.
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Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Hellemans J.,et al.Nat. Genet. 36:1213-1218(2004).
Lin F.,et al.Hum. Mol. Genet. 14:437-445(2005).
Pan D.,et al.J. Biol. Chem. 280:15992-16001(2005).
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