|Application ||WB, IHC-P, IF, E|
|Calculated MW||99997 Da|
|Dilution||IF (5 µg/ml), IHC-P (5 µg/ml), WB (1 µg/ml),|
|Other Names||LEMD3, MAN1, LEM domain containing 3|
|Target/Specificity||Human LEMD3. At least three isoforms of LEMD3 are known to exist; this antibody will detect all isoforms. LEMD3 antibody is predicted to not cross-react with LEMD1 and LEMD2|
|Reconstitution & Storage||PBS, 0.02% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||LEMD3 / MAN1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.|
|Cellular Location||Nucleus inner membrane; Multi-pass membrane protein|
|Tissue Location||Heart, brain, placenta, lung, liver and skeletal muscle|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.
Lin F.,et al.J. Biol. Chem. 275:4840-4847(2000).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Hellemans J.,et al.Nat. Genet. 36:1213-1218(2004).
Lin F.,et al.Hum. Mol. Genet. 14:437-445(2005).
Pan D.,et al.J. Biol. Chem. 280:15992-16001(2005).
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