|Application ||WB, IHC-P, IF|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||48760 Da|
|Dilution||IF (1:50 - 1:200), IHC-P (5 µg/ml), WB (1:500 - 1:1000),|
|Other Names||IL13RA1, Cancer/testis antigen 19, CD213A1, CD213a1 antigen, CT19, IL-13R-alpha-1, NR4, IL-13R subunit alpha-1, IL-13Ra, IL-13RA1, IL13R, IL13RA, IL-13 receptor subunit alpha-1, IL13 receptor alpha-1 chain|
|Target/Specificity||Human IL13RA1 / IL13R|
|Reconstitution & Storage||PBS, pH 7.2, 0.05% sodium azide. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.|
|Precautions||IL13RA1 Antibody (Lys401) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells|
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Provided below are standard protocols that you may find useful for product applications.
Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.
Miloux B.,et al.FEBS Lett. 401:163-166(1997).
Gauchat J.-F.,et al.Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
Aman M.J.,et al.J. Biol. Chem. 271:29265-29270(1996).
Wada M.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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