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TRIM45 Antibody (clone 3G3)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IF |
|---|---|
| Primary Accession | Q9H8W5 |
| Other Accession | 80263 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 3G3 |
| Calculated MW | 64359 Da |
| Dilution | IF (1:100), IHC-P (10 µg/ml), |
| Gene ID | 80263 |
|---|---|
| Other Names | TRIM45, RING finger protein 99, RNF99, Tripartite motif containing 45, Tripartite motif-containing 45 |
| Target/Specificity | Human TRIM45 |
| Reconstitution & Storage | PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing. |
| Precautions | TRIM45 Antibody (clone 3G3) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRIM45 |
|---|---|
| Synonyms | RNF99 |
| Function | E3 ubiquitin-protein ligase that plays a role in the regulation of inflammatory response (PubMed:36681779). Mechanistically, mediates the 'Lys-48'-linked polyubiquitination of TAB2, a regulatory protein of the kinase TAK1, leading to its degradation via the proteasomal pathway and inhibition of the TLR-mediated inflammatory immune response (PubMed:36681779). May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway. |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Expressed in skeletal muscle, brain, heart and pancreas. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
May act as a transcriptional repressor in mitogen- activated protein kinase signaling pathway.
References
Wang Y.,et al.Biochem. Biophys. Res. Commun. 323:9-16(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
Denis N.J.,et al.Proteomics 7:868-874(2007).
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