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TGFB1 / TGF Beta 1 Antibody
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E, Neut |
|---|---|
| Primary Accession | P01137 |
| Other Accession | 7040 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1,k |
| Calculated MW | 44325 Da |
| Dilution | IHC-P (10 µg/ml), WB (50 - 500 ng/ml), WB (50 - 500 ng/ml), |
| Gene ID | 7040 |
|---|---|
| Other Names | TGFB1, CED, DPD1, Diaphyseal dysplasia 1, LAP, Latency-associated peptide, TGF Beta, TGFbeta, TGF-beta 1 protein, TGF-beta-1, TGFB |
| Target/Specificity | Western Blot analysis demonstrates that This antibody reacts to either dimeric (25kD) or monomeric (12.5kD) molecules of TGF-b under non-reducing and reducing condition, respectively. Recognizes both human platelet-derived and recombinant TGF-b by ELISA. |
| Reconstitution & Storage | PBS, pH 7.0. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | TGFB1 / TGF Beta 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TGFB1 (HGNC:11766) |
|---|---|
| Synonyms | TGFB |
| Function | Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. |
| Cellular Location | [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix |
| Tissue Location | Highly expressed in bone (PubMed:11746498, PubMed:17827158). Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA) (PubMed:11746498, PubMed:17827158). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage (PubMed:17827158) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.
References
Derynck R.,et al.Nucleic Acids Res. 15:3188-3189(1987).
Derynck R.,et al.Nature 316:701-705(1985).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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