|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||134323 Da|
|Dilution||ELISA (1:20000), IHC-P (10 µg/ml), WB (1:500 - 1:1000),|
|Other Names||INTS2, Integrator complex subunit 2, INT2, KIAA1287|
|Target/Specificity||INTS2 Antibody detects endogenous levels of total INTS2 protein.|
|Reconstitution & Storage||PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.|
|Precautions||INTS2 / INT2 Antibody (aa201-250) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.|
|Cellular Location||Nucleus membrane; Single-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.
Nagase T.,et al.DNA Res. 6:337-345(1999).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Zody M.C.,et al.Nature 440:1045-1049(2006).
Baillat D.,et al.Cell 123:265-276(2005).
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