RAB38 Antibody (aa80-129)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | P57729 |
Other Accession | 23682 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 23712 Da |
Dilution | ELISA (1:20000), IHC-P (10 µg/ml), WB (1:500 - 1:1000), |
Gene ID | 23682 |
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Other Names | RAB38, Melanoma antigen NY-MEL-1, Ras-related protein Rab-38, RrGTPbp, NY-MEL-1 |
Target/Specificity | RAB38 Antibody detects endogenous levels of total RAB38 protein. |
Reconstitution & Storage | PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year. |
Precautions | RAB38 Antibody (aa80-129) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RAB38 |
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Function | May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). |
Cellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Melanosome membrane Note=Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization (PubMed:23084991) |
Tissue Location | Expressed in melanocytes. |
Volume | 50 µl |
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Background
May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.
References
Jaeger D.,et al.Cancer Res. 60:3584-3591(2000).
Kalnine N.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Basrur V.,et al.J. Proteome Res. 2:69-79(2003).
Chi A.,et al.J. Proteome Res. 5:3135-3144(2006).
Leung K.F.,et al.J. Biol. Chem. 282:1487-1497(2007).
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