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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SNK / PLK2 Antibody (aa291-340)   

SNK / PLK2 Antibody (aa291-340)

Rabbit Polyclonal Antibody

     
  • IHC - SNK / PLK2 Antibody (aa291-340) ALS16685
    Anti-SNK / PLK2 antibody IHC staining of human colon.
  • WB - SNK / PLK2 Antibody (aa291-340) ALS16685
    Western blot of extracts from HeLa/MCF-7 cells, using PLK2 Antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9NYY3
Other Accession 10769
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 78237 Da
Dilution ELISA (1:40000), IHC-P (10 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 10769
Other Names PLK2, HPlk2, HSNK, MSNK, PLK-2, Polo-like kinase 2, SNK, Serum inducible kinase snk, Serum-inducible kinase
Target/Specificity PLK2 Antibody detects endogenous levels of total PLK2 protein.
Reconstitution & Storage PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.
PrecautionsSNK / PLK2 Antibody (aa291-340) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLK2
Synonyms SNK
Function Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress.
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, dendrite. Note=Localizes to centrosomes during early G1 phase where it only associates to the mother centriole and then distributes equally to both mother and daughter centrioles at the onset of S phase
Tissue Location Expressed at higher level in the fetal lung, kidney, spleen and heart.
Volume 50 µl
Research Areas
Citations (0)

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Background

Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress.

References

Liby K.,et al.DNA Seq. 11:527-533(2001).
Anderson K.M.,et al.Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
Schmutz J.,et al.Nature 431:268-274(2004).
Fidler C.,et al.Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
Shimizu-Yoshida Y.,et al.Biochem. Biophys. Res. Commun. 289:491-498(2001).

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$ 395.00
Cat# ALS16685
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