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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   MAPK6 / ERK3 Antibody (aa461-510)   

MAPK6 / ERK3 Antibody (aa461-510)

Rabbit Polyclonal Antibody

     
  • IHC - MAPK6 / ERK3 Antibody (aa461-510) ALS16709
    Anti-MAPK6 / ERK3 antibody IHC staining of human heart.
  • IF - MAPK6 / ERK3 Antibody (aa461-510) ALS16709
    Immunofluorescence of MCF7 cells, using p97 MAPK Antibody.
  • WB - MAPK6 / ERK3 Antibody (aa461-510) ALS16709
    Western blot of extracts from K562 cells, using p97 MAPK Antibody.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q16659
Other Accession 5597
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 82681 Da
Dilution ELISA (1:5000), IF (1:100 - 1:500), IHC-P (10 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 5597
Other Names MAPK6, ERK-3, MAP kinase 6, MAPK 6, p97-MAPK, PRKM6, MAP kinase isoform p97, ERK3, HsT17250, p97MAPK
Target/Specificity p97 MAPK Antibody detects endogenous levels of total p97 MAPK protein.
Reconstitution & Storage PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.
PrecautionsMAPK6 / ERK3 Antibody (aa461-510) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAPK6
Synonyms ERK3, PRKM6
Function Atypical MAPK protein. Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity).
Cellular Location Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following interaction with MAPKAPK5.
Tissue Location Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts
Volume 50 µl
Research Areas
Citations (0)

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Background

Atypical MAPK protein. Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity).

References

Zhu A.X.,et al.Mol. Cell. Biol. 14:8202-8211(1994).
Meloche S.,et al.Oncogene 13:1575-1579(1996).
Saranath D.,et al.Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).

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$ 395.00
Cat# ALS16709
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