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FMR1 / FMRP Antibody (clone 1D10)

Mouse Monoclonal Antibody

     
  • IHC - FMR1 / FMRP Antibody (clone 1D10) ALS16717
    Anti-FMR1 / FMRP antibody IHC staining of human lung.
  • WB - FMR1 / FMRP Antibody (clone 1D10) ALS16717
    HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FMR1...
  • WB - FMR1 / FMRP Antibody (clone 1D10) ALS16717
    Western blot of extracts (35 ug) from 9 different cell lines by using anti-FMR1 monoclonal...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q06787
Other Accession 2332
Reactivity Human, Mouse, Rat, Monkey, Dog
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names 1D10
Calculated MW 71174 Da
Dilution IHC-P (10 µg/ml), WB (1:500 - 1:2000),
Additional Information
Gene ID 2332
Other Names FMR1, FMRP, POF, Protein FMR-1, Premature ovarian failure 1, Fragile X mental retardation 1, FRAXA, POF1
Target/Specificity Human FMR1 / FMRP
Reconstitution & Storage PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing.
PrecautionsFMR1 / FMRP Antibody (clone 1D10) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FMR1
Function Translation repressor. Component of the CYFIP1-EIF4E- FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA- binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).
Cellular Location Cytoplasm. Nucleus, nucleolus.
Tissue Location Highest levels found in neurons, brain, testis, placenta and lymphocytes. Also expressed in epithelial tissues and at very low levels in glial cells
Volume 50 µl
Research Areas
Citations (0)

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Background

Translation repressor. Component of the CYFIP1-EIF4E- FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA- binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).

References

Verkerk A.J.M.H.,et al.Cell 65:905-914(1991).
Verkerk A.J.M.H.,et al.Hum. Mol. Genet. 2:399-404(1993).
Verkerk A.J.H.M.,et al.Hum. Mol. Genet. 2:1348-1348(1993).
Corominas R.,et al.Nat. Commun. 5:3650-3650(2014).
Ross M.T.,et al.Nature 434:325-337(2005).

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$ 395.00
Cat# ALS16717
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