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Lysyl Oxidase / LOX Antibody (clone 9A11)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, FC |
|---|---|
| Primary Accession | P28300 |
| Other Accession | 4015 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 9A11 |
| Calculated MW | 46944 Da |
| Dilution | Flo (1:100), IF (1:50 - 1:100), IHC-P (10 µg/ml), WB (1:2000), |
| Gene ID | 4015 |
|---|---|
| Other Names | LOX, Lysyl oxidase, Protein-lysine 6-oxidase |
| Target/Specificity | Human Lysyl Oxidase / LOX |
| Reconstitution & Storage | PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing. |
| Precautions | Lysyl Oxidase / LOX Antibody (clone 9A11) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LOX |
|---|---|
| Function | Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity). |
| Cellular Location | Secreted. Secreted, extracellular space |
| Tissue Location | Heart, placenta, skeletal muscle, kidney, lung and pancreas. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression.
References
Haemaelaeinen E.-R.,et al.Genomics 11:508-516(1991).
Mariani T.J.,et al.Matrix 12:242-248(1992).
Kim Y.,et al.J. Biol. Chem. 270:7176-7182(1995).
Contente S.,et al.Mol. Cell. Biochem. 194:79-91(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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