|Application ||WB, IHC-P, IF, Flo|
|Calculated MW||46944 Da|
|Dilution||Flo (1:100), IF (1:50 - 1:100), IHC-P (10 µg/ml), WB (1:2000),|
|Other Names||LOX, Lysyl oxidase, Protein-lysine 6-oxidase|
|Target/Specificity||Human Lysyl Oxidase / LOX|
|Reconstitution & Storage||PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing.|
|Precautions||Lysyl Oxidase / LOX Antibody (clone 9A11) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression.|
|Cellular Location||Secreted, extracellular space.|
|Tissue Location||Heart, placenta, skeletal muscle, kidney, lung and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression.
Haemaelaeinen E.-R.,et al.Genomics 11:508-516(1991).
Mariani T.J.,et al.Matrix 12:242-248(1992).
Kim Y.,et al.J. Biol. Chem. 270:7176-7182(1995).
Contente S.,et al.Mol. Cell. Biochem. 194:79-91(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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