|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||133650 Da|
|Dilution||IHC-P (10 µg/ml), WB (1 - 2 µg/ml),|
|Other Names||TYK2, Tyrosine kinase 2, JTK1|
|Target/Specificity||At least three isoforms of TYK2 are known to exist; this antibody only detects the two longest isoforms.|
|Reconstitution & Storage||PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||TYK2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.|
|Tissue Location||Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines|
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Provided below are standard protocols that you may find useful for product applications.
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
Firmbach-Kraft I.,et al.Oncogene 5:1329-1336(1990).
Velazquez L.,et al.Cell 70:313-322(1992).
Krolewski J.J.,et al.Oncogene 5:277-282(1990).
Partanen J.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:8913-8917(1990).
Colamonici O.,et al.Mol. Cell. Biol. 14:8133-8142(1994).
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