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BCL3 / BCL-3 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P20749 |
| Other Accession | 602 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 47584 Da |
| Dilution | IHC-P (10 µg/ml), WB (1 - 2 µg/ml), |
| Gene ID | 602 |
|---|---|
| Other Names | BCL3, B-cell CLL/lymphoma 3, B-cell leukemia/lymphoma 3, B-cell lymphoma 3 protein, BCL-3, BCL4, D19S37, Proto-oncogene BCL3 |
| Target/Specificity | Human BCL3 / BCL-3 |
| Reconstitution & Storage | PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | BCL3 / BCL-3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BCL3 |
|---|---|
| Synonyms | BCL4, D19S37 |
| Function | Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity). |
| Cellular Location | Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Ubiquitination via 'Lys-63'- linked ubiquitin chains is required for nuclear accumulation |
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Provided below are standard protocols that you may find useful for product applications.
Background
Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).
References
Ohno H.,et al.Cell 60:991-997(1990).
McKeithan T.W.,et al.Genomics 24:120-126(1994).
Bours V.,et al.Cell 72:729-739(1993).
Heissmeyer V.,et al.EMBO J. 18:4766-4778(1999).
Dechend R.,et al.Oncogene 18:3316-3323(1999).
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