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>   home   >   Products   >   Primary Antibodies   >   KANK2 Antibody (C-Terminus)   

KANK2 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - KANK2 Antibody (C-Terminus) ALS16757
    Anti-KANK2 antibody IHC staining of human kidney.
  • IHC - KANK2 Antibody (C-Terminus) ALS16757
    Anti-KANK2 antibody IHC staining of human testis.
  • IF - KANK2 Antibody (C-Terminus) ALS16757
    Immunofluorescence of KANK2 in human kidney tissue with KANK2 antibody at 20 ug/ml.
  • WB - KANK2 Antibody (C-Terminus) ALS16757
    Western blot analysis of KANK2 in mouse brain tissue lysate with KANK2 antibody at 1 ug/ml in...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q63ZY3
Other Accession 25959
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 91174 Da
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 µg/ml),
Additional Information
Gene ID 25959
Other Names KANK2, Ankyrin repeat domain 25, KIAA1518, ANKRD25, SIP, SRC-1-interacting protein, SRC1-interacting protein, MXRA3, SRC-1 interacting protein
Target/Specificity Two alternatively spliced transcript variants encoding different isoforms have been identified.
Reconstitution & Storage PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsKANK2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KANK2
Synonyms ANKRD25, KIAA1518, MXRA3, SIP
Function Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus (PubMed:22371500). May be involved in promotion of cell proliferation (By similarity).
Cellular Location Cytoplasm. Mitochondrion.
Tissue Location Strongly expressed in cervix, colon, heart, kidney and lung. Expressed in kidney glomerular podocytes and mesangial cells (at protein level).
Citations (0)

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Background

Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus (PubMed:22371500). May be involved in promotion of cell proliferation (By similarity).

References

Zhang Y.,et al.EMBO J. 26:2645-2657(2007).
Zhu Y.,et al.Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 7:143-150(2000).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS16757
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