|Application ||WB, IHC-P, IF, E|
|Calculated MW||15503 Da|
|Dilution||IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 µg/ml),|
|Other Names||TMEM107, Transmembrane protein 107, GRVS638, PRO1268|
|Target/Specificity||TMEM107 antibody is human specific. At least two isoforms of TMEM107 are known to exist.|
|Reconstitution & Storage||PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||TMEM107 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein|
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Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity).
Xu X.,et al.Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
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