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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   IL1RL2 Antibody (Internal)   

IL1RL2 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - IL1RL2 Antibody (Internal) ALS16774
    Anti-IL1RL2 antibody IHC staining of human heart.
  • IF - IL1RL2 Antibody (Internal) ALS16774
    Immunofluorescence of IL-1RL2 in human small intestine tissue with IL-1RL2 antibody at 20 ug/ml.
  • WB - IL1RL2 Antibody (Internal) ALS16774
    Western blot analysis of IL-1RL2 in human small intestine lysate with IL-1RL2 antibody at (A) 1...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q9HB29
Other Accession 8808
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 65405 Da
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 - 2 µg/ml),
Additional Information
Gene ID 8808
Other Names IL1RL2, IL-1Rrp2, IL1R-rp2, IL1RRP2, Interleukin 1 receptor-like 2, Interleukin-1 receptor-like 2, IL-36R
Target/Specificity IL-1RL2 antibody is human, mouse and rat reactive. At least three isoforms of IL-1RL2 are known to exist; this antibody will detect all three isoforms. IL-1RL2 antibody is predicted to not cross-react with IL-1R or IL-1RL1.
Reconstitution & Storage PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsIL1RL2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL1RL2
Synonyms IL1RRP2
Function Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL- 23/IL-17/IL-22 pathway.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte- derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level.
Research Areas
Citations (0)

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Background

Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL- 23/IL-17/IL-22 pathway.

References

Born T.L.,et al.J. Biol. Chem. 275:29946-29954(2000).
Lovenberg T.W.,et al.J. Neuroimmunol. 70:113-122(1996).
Hillier L.W.,et al.Nature 434:724-731(2005).
Debets R.,et al.J. Immunol. 167:1440-1446(2001).
Magne D.,et al.Arthritis Res. Ther. 8:R80-R80(2006).

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$ 395.00
Cat# ALS16774
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