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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   NOS2 / iNOS Antibody (clone K13-A)   

NOS2 / iNOS Antibody (clone K13-A)

Rabbit Polyclonal Antibody

     
  • IHC - NOS2 / iNOS Antibody (clone K13-A) ALS16792
    Anti-NOS2 / iNOS antibody IHC staining of human liver.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IHC-Fr
Primary Accession P35228
Other Accession 4843
Reactivity Human
Host Rabbit
Clonality Polyclonal
Clone Names K13-A
Calculated MW 131117 Da
Dilution IHC-P (1:200),
Additional Information
Gene ID 4843
Other Names NOS2, Hepatocyte NOS, HEP-NOS, Inducible NOS, NOS, type II, NOS type II, Inducible NO synthase, NOS2A, INOS, NOS
Reconstitution & Storage 20 mM Tris-HCl, pH 8.0, 20 mg/ml BSA stabilzer, 0.05% NaN3 preservative. +4°C, avoid freezing
PrecautionsNOS2 / iNOS Antibody (clone K13-A) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NOS2
Synonyms NOS2A
Function Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109).
Tissue Location Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets
Volume 50 µl
Research Areas
Citations (0)

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Background

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.

References

Sherman P.A.,et al.Biochemistry 32:11600-11605(1993).
Geller D.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:3491-3495(1993).
Charles I.G.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:11419-11423(1993).
Maier R.,et al.Biochim. Biophys. Acta 1208:145-150(1994).
Park C.S.,et al.Biochem. Biophys. Res. Commun. 205:85-91(1994).

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$ 395.00
Cat# ALS16792
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