|Application ||IHC-P, IHC-Fr|
|Calculated MW||131117 Da|
|Other Names||NOS2, Hepatocyte NOS, HEP-NOS, Inducible NOS, NOS, type II, NOS type II, Inducible NO synthase, NOS2A, INOS, NOS|
|Reconstitution & Storage||20 mM Tris-HCl, pH 8.0, 20 mg/ml BSA stabilzer, 0.05% NaN3 preservative. +4°C, avoid freezing|
|Precautions||NOS2 / iNOS Antibody (clone K13-A) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109).|
|Tissue Location||Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
Sherman P.A.,et al.Biochemistry 32:11600-11605(1993).
Geller D.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:3491-3495(1993).
Charles I.G.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:11419-11423(1993).
Maier R.,et al.Biochim. Biophys. Acta 1208:145-150(1994).
Park C.S.,et al.Biochem. Biophys. Res. Commun. 205:85-91(1994).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.