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INA / Alpha Internexin Antibody (clone 2E3)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IHC-P, IF |
|---|---|
| Primary Accession | Q16352 |
| Other Accession | 9118 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 2E3 |
| Calculated MW | 55391 Da |
| Dilution | IF (1:500), IHC (1:5000), IHC-P (1:50), WB (1:10000), |
| Gene ID | 9118 |
|---|---|
| Other Names | INA, 66 kDa neurofilament protein, Alpha Internexin, Alpha-internexin, Alpha-Inx, NEF5, Neurofilament 5, Neurofilament-66, NF-66, TXBP-1, Neurofilament 5 (66kD) |
| Target/Specificity | Clone 2E3 reacts with human alpha-internexin and with this protein in all mammalian species tested to date. |
| Reconstitution & Storage | Tissue culture supernatant. +4°C or -20°C, Avoid repeated freezing and thawing. |
| Precautions | INA / Alpha Internexin Antibody (clone 2E3) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | INA |
|---|---|
| Synonyms | NEF5 |
| Function | Class-IV neuronal intermediate filament that is able to self- assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NEFL to form the filamentous backbone to which NEFM and NEFH attach to form the cross-bridges. May also cooperate with the neuronal intermediate filament protein PRPH to form filamentous networks (By similarity). |
| Tissue Location | Found predominantly in adult CNS. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges.
References
Chan S.-O.,et al.Brain Res. Mol. Brain Res. 29:177-184(1995).
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Lubec G.,et al.Submitted (DEC-2008) to UniProtKB.
Matsuoka S.,et al.Science 316:1160-1166(2007).
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