|Application ||WB, IHC-P, E|
|Calculated MW||88584 Da|
|Dilution||IHC-P (10 µg/ml),|
|Other Names||AFG3L2, AFG3-like protein 2, SPAX5, Spinocerebellar ataxia 28, Paraplegin-like protein, ATPase family gene 3, yeast, SCA28|
|Reconstitution & Storage||PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.|
|Precautions||AFG3L2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||ATP-dependent protease which is essential for axonal and neuron development. In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU.|
|Cellular Location||Mitochondrion membrane; Multi-pass membrane protein|
|Tissue Location||Ubiquitous. Highly expressed in the cerebellar Purkinje cells.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
ATP-dependent protease which is essential for axonal development.
Banfi S.,et al.Genomics 59:51-58(1999).
Atorino L.,et al.J. Cell Biol. 163:777-787(2003).
Koppen M.,et al.Mol. Cell. Biol. 27:758-767(2007).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
Edener U.,et al.Eur. J. Hum. Genet. 18:965-968(2010).
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