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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   FSP27 / CIDEC Antibody   

FSP27 / CIDEC Antibody

Rabbit Polyclonal Antibody

     
  • IHC - FSP27 / CIDEC Antibody ALS16911
    Anti-FSP27 / CIDEC antibody IHC staining of human liver.
  • IF - FSP27 / CIDEC Antibody ALS16911
    CIDEC antibody detects CIDEC protein at cytoplasm by immunofluorescent analysis.
  • WB - FSP27 / CIDEC Antibody ALS16911
    Sample (30 ug of whole cell lysate) A: HeLa B: HepG2 12% SDS PAGE CIDEC / FSP27 antibody diluted...
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC
Primary Accession Q96AQ7
Other Accession 63924
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 26754 Da
Dilution ICC (1:100 - 1:1000), IF (1:100 - 1:1000), IHC-P (7.5 µg/ml), WB (1:500 - 1:3000),
Additional Information
Gene ID 63924
Other Names CIDEC, CIDE3, CIDE-3, FSP27, Cell death activator CIDE-3, CIDEX, Fat specific protein 27
Target/Specificity Human CIDEC / FSP27
Reconstitution & Storage PBS, pH 7, 1% BSA, 20% Glycerol, 0.01% Thimerosal. Aliquot and freeze at -20° C. Avoid freeze-thaw cycles.
PrecautionsFSP27 / CIDEC Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CIDEC
Synonyms FSP27
Function Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression.
Cellular Location Nucleus. Endoplasmic reticulum. Lipid droplet. Note=Diffuses quickly on lipid droplet surface, but becomes trapped and clustered at lipid droplet contact sites, thereby enabling its rapid enrichment at lipid droplet contact sites
Tissue Location Expressed mainly in adipose tissue, small intestine, heart, colon and stomach and, at lower levels, in brain, kidney and liver.
Volume 50 µl
Research Areas
Citations (0)

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Background

Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression.

References

Liang L.,et al.Biochem. J. 370:195-203(2003).
Liang L.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Keller P.,et al.J. Biol. Chem. 283:14355-14365(2008).

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$ 395.00
Cat# ALS16911
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