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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PPP3CA / CCN1 / Calcineurin A Antibody (aa364-283)   

PPP3CA / CCN1 / Calcineurin A Antibody (aa364-283)

Rabbit Polyclonal Antibody

     
  • IHC - PPP3CA / CCN1 / Calcineurin A Antibody (aa364-283) ALS16925
    Anti-PPP3CA / CCN1 / Calcineurin A antibody IHC staining of human brain, cerebellum.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IP
Primary Accession Q08209
Other Accession 5530
Reactivity Human, Mouse, Rat, Rabbit, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 58688 Da
Dilution IHC-P (5 µg/ml), WB (1:1000),
Additional Information
Gene ID 5530
Other Names PPP3CA, Calcineurin A, CALN, CALNA, CALNA1, CNA1, PPP2B, Calcineurin A alpha, CAM-PRP catalytic subunit, CCN1, CNA, CNA alpha, pp2b-alpha
Target/Specificity Identifies a band at ~61kD on a WB.
Reconstitution & Storage PBS, pH 7.4; 50% glycerol, 0.09% sodium azide. Store at -20°C.
PrecautionsPPP3CA / CCN1 / Calcineurin A Antibody (aa364-283) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPP3CA (HGNC:9314)
Synonyms CALNA, CNA
Function Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (PubMed:17498738, PubMed:17502104, PubMed:23468591, PubMed:27974827, PubMed:22343722). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (PubMed:18838687). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). In response to increased Ca(2+) levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation (PubMed:26248042). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138).
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P63329}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:P63329}. Cell projection, dendritic spine. Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (By similarity). Recruited to the cell membrane by scaffold protein AKAP5 following L-type Ca(2+)-channel activation (PubMed:22343722). {ECO:0000250|UniProtKB:P63329, ECO:0000269|PubMed:22343722}
Volume 50 µl
Research Areas
Citations (0)

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Background

Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.

References

Muramatsu T.,et al.Biochim. Biophys. Acta 1178:117-120(1993).
Chiocco M.J.,et al.Subst. Use Misuse 45:1809-1826(2010).
Landreville S.,et al.Mol. Vis. 17:1324-1333(2011).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).

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$ 425.00
Cat# ALS16925
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