|Application ||WB, IHC-P, IP|
|Reactivity||Human, Mouse, Rat, Rabbit, Dog|
|Calculated MW||58688 Da|
|Dilution||IHC-P (5 µg/ml), WB (1:1000),|
|Other Names||PPP3CA, Calcineurin A, CALN, CALNA, CALNA1, CNA1, PPP2B, Calcineurin A alpha, CAM-PRP catalytic subunit, CCN1, CNA, CNA alpha, pp2b-alpha|
|Target/Specificity||Identifies a band at ~61kD on a WB.|
|Reconstitution & Storage||PBS, pH 7.4; 50% glycerol, 0.09% sodium azide. Store at -20°C.|
|Precautions||PPP3CA / CCN1 / Calcineurin A Antibody (aa364-283) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.|
|Cellular Location||Cell membrane. Cell membrane, sarcolemma. Nucleus. Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.
Muramatsu T.,et al.Biochim. Biophys. Acta 1178:117-120(1993).
Chiocco M.J.,et al.Subst. Use Misuse 45:1809-1826(2010).
Landreville S.,et al.Mol. Vis. 17:1324-1333(2011).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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