|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||100292 Da|
|Dilution||ELISA (1:10000), IHC-P (5 µg/ml), WB (1:500 - 1:1000),|
|Other Names||WFS1, DIDMOAD, DFNA14, DFNA6, Wolframin, WFS, WFSL, Wolfram syndrome 1 (wolframin), DFNA38, WFRS, Wolfram Syndrome 1|
|Target/Specificity||Wolframin antibody detects endogenous levels of Wolframin.|
|Reconstitution & Storage||PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C.|
|Precautions||WFS1 Antibody (aa183-232) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in heart followed by brain, placenta, lung and pancreas. Weakly expressed in liver, kidney and skeletal muscle. Also expressed in islet and beta-cell insulinoma cell line|
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Provided below are standard protocols that you may find useful for product applications.
Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store.
Strom T.M.,et al.Hum. Mol. Genet. 7:2021-2028(1998).
Inoue H.,et al.Nat. Genet. 20:143-148(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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